Modification of collagen by 3-deoxyglucosone alters wound healing through differential regulation of p38 MAP kinase. Circulating immune complexes do not affect microparticle flow cytometry analysis in acute coronary syndrome. Does endothelin mediate endothelium-dependent contractions during anoxia? Differential effect of cyclic GMP on the release of endothelin from cultured endothelial cells and from intact porcine aorta. Expert Opin Emerg Drugs. Am J Physiol Cell Physiol.

Circulating platelet derived microparticles are not increased in patients with cirrhosis. Microvesicles and exosomes in cardiovascular diseases. Role of microparticles on atherothrombosis. One of the main challenges for the diabetic wound healing is the structuring of a normal matrix in quantity and quality. Effects of tumor necrosis factor-alpha TNF alpha in epidermal keratinocytes revealed using global transcriptional profiling.

In parallel, the endothelial cells per se seem to be a very sensitive target to high glucose.

Chronic wounds and especially diabetic foot ulcers exhibit a highly pro-oxidant microenvironment that amplifies the cytotoxic cascade. J Cardiovasc Pharmacol 17, SS, Endothelium-dependent control of vascular tone: Under a number of circumstances, Foxo transcription factors induce the expression of BIM and other pro-apoptotic genes.

This is ethiopathogenically multifactorial and behaves as individual as the affected subject is.

william benessiano curriculum vitae

Circulation Res5: There are numerous cellular and molecular aspects unknown and that remain to be answered on the granulation tissue biology, such as: Biology of the Diabetic Wound. Chemokines, cytokines, and growth factors in keratinocytes and dermal endothelial cells in the margin of chronic diabetic foot ulcers. For subjects with macrovascular disease, the defective angiogenesis prolongs and disturbs the healing process. British Benessianoo Pharmacol, Blood,9: Fibronectin degradation, for instance, is referred as one among the several causes of diabetic re-epithelialization failure.


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Endothelium-dependent response in hypertension. Decreased replicative capacity of cultured skin fibroblasts.

Diabetic foot ulcers and vascular insufficiency: Under more mature stages, the neuropathics may also show an abnormal sprout of beenssiano small vessels and capillaries that may derive not from a normal angiogenic response but due to arterio-venous shunts.

Anabolic action of insulin on skin wound protein is augmented by exogenous amino acids. Other evidences indicate that PMN are critical toward the acquisition and perpetuation of inflammation and a degradative phenotype.

william benessiano curriculum vitae

Expert Opin Emerg Drugs. Blanc-Brude, Boulanger, Noel, Jorgensen.

William Benessiano

Studies with human fibroblasts have confirmed the pro-degradative phenotype by the increased MMP-2 and MMP-3 production and reduced collagens gene expression [31]. Blockade of advanced glycation end-product formation restores ischemia-induced angiogenesis in diabetic mice. Methods to characterize patients suffering from hemolysis, patent filled 9 mars EP As diabetes courses with a deficient secretion of growth factors and other chemotactic mediators in areas of tissue repair, recruitment of circulating stromal cells appears reduced; which may turn into an additional hit to that of high glucose-associated toxicity [].


Cultured fibroblasts from chronic diabetic wounds on the lower extremity non-insulin-dependent diabetes mellitus show disturbed proliferation. dilliam

william benessiano curriculum vitae

The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. Impairment in ischemia-induced neovascularization in diabetes: Chapman and Hall, London,pp Influence benesskano endothelial surface on flow velocity in vitro. Physiology and role in liver diseases. Fibrocytes contribute to the myofibroblast population in wounded skin and originate from the bone benesssiano.

Impaired wound healing in an acute diabetic pig model and the effects of local hyperglycemia. Effects of tumor necrosis factor-alpha TNF alpha in epidermal keratinocytes revealed using global transcriptional profiling.